David was 36 years old when he was diagnosed with Helicobacter pylori in 2021 – a bacterial infection of the stomach. However, due to a documented penicillin allergy from childhood,
The study enrolled 382 adults, including David, who were assessed using a specialised risk assessment tool called PEN-FAST. Participants were randomly assigned to receive either a direct oral penicillin challenge or the standard approach, which involves penicillin skin testing followed by an oral challenge. The primary goal was to determine if the direct oral
“After the PALACE Study, it’s allowed me to have a much smoother treatment to eradicate the h’plyori. It’s great being able to move forward knowing I can have penicillin as an option which gives me a lot of comfort.
The findings of the PALACE study have wide-ranging implications, particularly for the more than two million Australians who will have access to the simplified penicillin allergy testing procedure. By accurately identifying low-risk penicillin allergy patients
the way for the widespread adoption of the direct oral penicillin challenge as a safe and effective alternative to traditional skin testing.
n the field of laboratory medicine we operate the most technologically advanced diagnostic systems, analyzing approximately three and a half million specimens a year. This testing is supervised by a team of physician scientists who are leaders in the fields of hematology,
Our Department is fully accredited by, and is a participant in the Quality Assurance programs of the College of American Pathologists.
